Description
A diterpenoid with diverse biological activities; inhibits Gram-positive and Gram-negative bacterial growth in disc diffusion assays (MICs = 39-156 and 312.5-625 μg/ml, respectively); reduces K652 cell viability (IC50 = 18.19 μg/ml); reduces motor deficit, delays disease onset, and downregulates inflammatory CD4+IFN-γ+ Th1 cells and CD4+IL-17A+ Th7 cells in a mouse model of EAE at 2 mg/kg; reduces the arthritis index, NF-kB activity, and paw swelling and increases annexin-1 expression in a rat model of collagen-induced arthritis from 1-4 mg/kg; topical administration reduces edema induced carrageenan, CFA, and formalin in rats at 0.3-0.5% w/w
Formal name: (α7R,1R,3S,4aS,4bR,7S,10aS)-1,2,3,4,4a,4b,5,6,7,9,10,10a-dodecahydro-3-hydroxy-α7-(hydroxymethyl)-1,4a,7-trimethyl-1,7-phenanthrenedimethanol
Synonyms:
Molecular weight: 338.5
CAS: 52659-56-0
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Microtubule Dynamics||Product Type|Biochemicals|Natural Products|Terpenes||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Immunology & Inflammation|Autoimmunity|Rheumatoid Arthritis||Research Area|Infectious Disease|Bacterial Diseases
