A diterpenoid with diverse biological activities; inhibits Gram-positive and Gram-negative bacterial growth in disc diffusion assays (MICs = 39-156 and 312.5-625 μg/ml

Kirenol – 10 mg

Brand:
Cayman
CAS:
52659-56-0
Storage:
-20
UN-No:
Non-Hazardous - /

Kirenol is a diterpenoid that has been found in S. orientalis and has diverse biological activities, including anti-arthritic and anti-inflammatory properties.{43582,43583} It inhibits Gram-positive and Gram-negative bacterial growth in disc diffusion assays with MICs ranging from 39 to 156 and 312.5 to 625 μg/ml, respectively.{43584} Kirenol also reduces K652 chronic myeloid leukemia cell viability with a 48 hour IC50 value of 18.19 μg/ml and induces apoptosis.{43585} In vivo, kirenol (2 mg/kg, p.o.) reduces motor deficit, delays disease onset by approximately five days, and downregulates inflammatory CD4+IFN-γ+ Th1 cells and CD4+IL-17A+ Th17 cells in a mouse model of experimental autoimmune encephalomyelitis (EAE).{43586} Intragastric administration of kirenol (1-4 mg/kg) reduces the arthritis index, NF-kB activity, and paw swelling and increases annexin-1 expression without affecting glucocorticoid receptor α (GRα) expression in the synovium in a rat model of collagen-induced arthritis.{43582} Topical administration of kirenol (0.3-0.5% w/w) reduces edema induced by carrageenan, complete Freund’s adjuvant (CFA), and formalin in rats up to 44, 67, and 65%, respectively.{43583}  

 

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Description

A diterpenoid with diverse biological activities; inhibits Gram-positive and Gram-negative bacterial growth in disc diffusion assays (MICs = 39-156 and 312.5-625 μg/ml, respectively); reduces K652 cell viability (IC50 = 18.19 μg/ml); reduces motor deficit, delays disease onset, and downregulates inflammatory CD4+IFN-γ+ Th1 cells and CD4+IL-17A+ Th7 cells in a mouse model of EAE at 2 mg/kg; reduces the arthritis index, NF-kB activity, and paw swelling and increases annexin-1 expression in a rat model of collagen-induced arthritis from 1-4 mg/kg; topical administration reduces edema induced carrageenan, CFA, and formalin in rats at 0.3-0.5% w/w

Formal name: (α7R,1R,3S,4aS,4bR,7S,10aS)-1,2,3,4,4a,4b,5,6,7,9,10,10a-dodecahydro-3-hydroxy-α7-(hydroxymethyl)-1,4a,7-trimethyl-1,7-phenanthrenedimethanol

Synonyms: 

Molecular weight: 338.5

CAS: 52659-56-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Microtubule Dynamics||Product Type|Biochemicals|Natural Products|Terpenes||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Immunology & Inflammation|Autoimmunity|Rheumatoid Arthritis||Research Area|Infectious Disease|Bacterial Diseases

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