A glycoside with diverse biological activities; increases adipose triglyceride lipase-mediated lipolysis and hydrolysis of triglycerides in C3H10T1/2 adipocytes; increases phosphorylation of PPARα and CREB in adipocytes in vitro; decreases the production of IFN-γ

Kinsenoside – 10 mg

Brand:
Cayman
CAS:
151870-74-5
Storage:
-20
UN-No:
Non-Hazardous - /

Kinsenoside is a glycoside originally isolated from A. formosanus that has diverse biological activities, including antihyperlipidemic, immunosuppressive, and anti-inflammatory properties.{37649,37650,37651,37652} It increases lipolysis mediated by adipose triglyceride lipase and increases hydrolysis of triglycerides in C3H10T1/2 adipocytes.{37650} It also increases phosphorylation of peroxisome proliferator-activated receptor α (PPARα) and CREB as well as protein levels of SIRT1, PGC-1α, and carnitine palmitoyltransferase I. Kinsenoside downregulates the expression and phosphorylation of VEGF receptor 2 (VEGFR2) and inhibits crosstalk between the JAK2/STAT3 and PI3K/AKT signaling pathways in dendritic cells in vitro.{37652} It decreases the production of IFN-γ, IL-17, and TNF-α and increases the production of IL-10 in splenocytes isolated from mice with collagen-induced arthritis (CIA).{37651} Kinsenoside (300 mg/kg per day) decreases the expression of IL-1β, TNF-α, and matrix metalloproteinase-9 (MMP-9) and increases the expression of IL-10 in inflamed joints in a mouse model of collagen-induced arthritis and prevents paw edema and reduces the severity of arthritis.  

 

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SKU: 25144 - 10 mg Category:

Description

A glycoside with diverse biological activities; increases adipose triglyceride lipase-mediated lipolysis and hydrolysis of triglycerides in C3H10T1/2 adipocytes; increases phosphorylation of PPARα and CREB in adipocytes in vitro; decreases the production of IFN-γ, IL-17, and TNF-α and increases the production of IL-10 in splenocytes isolated from mice with CIA; decreases the expression of IL-1β, TNF-α, and MMP-9 and increases the expression of IL-10 in inflamed joints of mice with CIA at 300 mg/kg

Formal name: 4R-(β-D-glucopyranosyloxy)dihydro-2(3H)-furanone

Synonyms:  (+)-Kinsenoside

Molecular weight: 264.2

CAS: 151870-74-5

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Glycosides||Research Area|Immunology & Inflammation|Autoimmunity|Rheumatoid Arthritis||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Lipid Biochemistry|Sterol Lipids

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