An activator of the RLR pathway; induces IRF3 activation and translocation into the nucleus in a concentration-dependent manner in HEK293 cells without inducing cellular toxicity; induces expression of the innate immune genes MDA5

KIN1408 – 5 mg

Brand:
Cayman
CAS:
1903800-11-2
Storage:
-20
UN-No:
Non-Hazardous - /

KIN1408 is a small molecule activator of the RIG-1-like receptor (RLR) pathway that has antiviral activity.{41564} It induces interferon regulatory factor 3 (IRF3) activation and translocation into the nucleus in a concentration-dependent manner in HEK293 cells without inducing cellular toxicity. KIN1408 induces expression of the innate immune genes MDA5, RIG-1, Mx1, IRF7, and IFIT1 in THP-1 cells stimulated with phorbol 12-myristate 12-acetate (PMA; Item No. 10008014). It exhibits concentration-dependent broad-spectrum antiviral activity against dengue virus 2 as well as the influenza A, Ebola, Nipah, and Lassa viruses.  

 

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Description

An activator of the RLR pathway; induces IRF3 activation and translocation into the nucleus in a concentration-dependent manner in HEK293 cells without inducing cellular toxicity; induces expression of the innate immune genes MDA5, RIG-1, Mx1, IRF7, and IFIT1 in PMA-stimulated THP-1 cells; exhibits concentration-dependent broad-spectrum antiviral activity

Formal name: 7-[[4-(difluoromethoxy)phenyl][(5-methoxy-2-benzothiazolyl)amino]methyl]-8-quinolinol

Synonyms: 

Molecular weight: 479.5

CAS: 1903800-11-2

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Antivirals||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Infectious Disease|Viral Diseases|Dengue||Research Area|Infectious Disease|Viral Diseases|Ebola||Research Area|Infectious Disease|Viral Diseases|Influenza

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