An activator of the RLR pathway; induces expression of the innate immune genes RIG-1

KIN1400 – 5 mg

Brand:
Cayman
CAS:
446826-86-4
Storage:
-20
UN-No:
Non-Hazardous - /

KIN1400 is a small molecule activator of the RIG-1-like receptor (RLR) pathway that has antiviral activity.{41564} It induces expression of the innate immune genes RIG-1, MDA5, IFIT1, IFIT2, IFITM1, OAS3, and Mx1 in THP-1 cells stimulated with phorbol 12-myristate 13-acetate (PMA; Item No. 10008014). KIN1400 (20 μM) reduces West Nile and dengue viral RNA levels in HEK293 and Huh7 cells, respectively. It also inhibits hepatitis C virus (HCV) replication in a concentration-dependent manner in Huh7 cells.  

 

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Description

An activator of the RLR pathway; induces expression of the innate immune genes RIG-1, MDA5, IFIT1, IFIT2, IFITM1, OAS3, and Mx1 in PMA-stimulated THP-1 cells; reduces West Nile and dengue viral RNA levels in HEK293 and Huh7 cells, respectively (20 μM); inhibits HCV replication in a concentration-dependent manner in Huh7 cells

Formal name: 7-[(2-benzothiazolylamino)[4-(difluoromethoxy)phenyl]methyl]-8-quinolinol

Synonyms: 

Molecular weight: 449.5

CAS: 446826-86-4

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Receptor Pharmacology||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Infectious Disease|Viral Diseases|Dengue||Research Area|Infectious Disease|Viral Diseases|Hepatitis||Research Area|Infectious Disease|Viral Diseases|West Nile Virus

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