Inhibits PANC-1 cell survival in nutrient-deprived media at a 100-fold lower concentration than that required for cells maintained in nutrient-rich media

Kigamicin C – 500 µg

Brand:
Cayman
CAS:
680571-51-1
Storage:
-20
UN-No:
Non-Hazardous - /

Kigamicins are natural antitumor antibiotics that selectively kill pancreatic cancer PANC-1 cells only under nutrient-starved conditions.{31088} They also show antimicrobial activity against Gram-positive bacteria, including methicillin-resistant S. aureus. Kigamicin C inhibits PANC-1 cell survival in nutrient-deprived media at a 100-fold lower concentration than that required for cells maintained in nutrient-rich media.{31088} A related compound, kigamicin D, is active in vivo, suppressing the tumor growth of several pancreatic cancer cell lines in nude mice.{31089} It blocks the activation of Akt induced in PANC-1 cells placed in nutrient-deprived media.{31089} Kigamicin can also induce necrosis in human myeloma cells, but not normal lymphocytes, maintained in nutrient-rich media (CC50 = 100 nM).{31090}  

 

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Description

Inhibits PANC-1 cell survival in nutrient-deprived media at a 100-fold lower concentration than that required for cells maintained in nutrient-rich media

Formal name: (1S,3R,4S,8aR,11aR)-3-[[(2S,5S,6R)-5-[(2,6-dideoxy-3-O-methyl-b-D-arabinohexopyranosyl)oxy]tetrahydro-6-methyl-2H-pyran-2-yl]oxy]-1,2,3,4,8a,9,11,11a,13,14-decahydro-1,4,17,18-tetrahydroxy-11a-methyl-oxazolo[3,2-b]xantheno[4′,3′,2′:4,5][1,3]benzodioxino[7,6-g]isoquinoline-16,19-dione

Synonyms: 

Molecular weight: 809.8

CAS: 680571-51-1

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals||Research Area|Cancer|Cell Death|Necrosis

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