A potent and selective inhibitor of class I α-mannosidases and serves as a key inhibitor of glycoprotein biosynthesis; inhibits both human ER α-1

Kifunensine – 10 mg

Brand:
Cayman
CAS:
109944-15-2
Storage:
-20
UN-No:
Non-Hazardous - /

Kifunensine was originally isolated from the actinomycete Kitasatosporia kifunensine No. 9482 and shown to be a weak inhibitor of aryl mannosidase.{14697,14696} It has since been shown to be a potent and selective inhibitor of class I α-mannosidases and may serve as a key inhibitor of glycoprotein biosynthesis.{14695} Kifunensine inhibits both human endoplasmic reticulum α-1,2-mannosidase I and members of the Golgi subfamily of the class I mannosidases (Golgi α-mannosidase IA, IB, and IC) exhibiting Ki values of 130 and 23 nM, respectively. It also inhibits mung bean α-1,2-mannosidase I with an IC50 value of 20-50 nM.{14695} Kifunensine can be used to block α-mannosidase I activity at the endoplasmic reticulum (ER), preventing the removal of desired mutated proteins through ER quality control mechanisms.{24763,24762}  

 

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SKU: 10009437 - 10 mg Category:

Description

A potent and selective inhibitor of class I α-mannosidases and serves as a key inhibitor of glycoprotein biosynthesis; inhibits both human ER α-1,2-mannosidase I and Golgi class I mannosidases (Golgi α-mannosidase IA, IB, and IC) exhibiting Ki values of 130 and 23 nM, respectively; inhibits mung bean α-1,2-mannosidase I with an IC50 value of 20-50 nM

Formal name: hexahydro-6R,7S,8aS-trihydroxy-5R-(hydroxymethyl)-imidazo[1,2-a]pyridine-2,3-dione

Synonyms:  FR900494

Molecular weight: 232.2

CAS: 109944-15-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cell Biology|Endomembrane System & Vesicular Trafficking

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