A c-Fms kinase inhibitor (IC50 = 2 nM); inhibits CSF1-dependent c-Fms phosphorylation in a dose-dependent manner in RAW264.7 cells; reduces CSF1-dependent growth of M-NFS-60 cells (IC50 = 14 nM); suppresses development of TRAP-positive osteoclast-like cells from murine bone marrow (IC50 = 40 nM); decreases the number and area of osteolytic lesions on femurs and tibiae in a murine A375 subcutaneous xenograft model; reduces TNF-α infiltration and osteolytic bone destruction in a CIA mouse model

Ki20227 – 1 mg

Brand:
Cayman
CAS:
623142-96-1
Storage:
-20
UN-No:
Non-Hazardous - /

Ki20227 is an inhibitor of macrophage colony stimulating factor 1 (CSF1) receptor tyrosine kinase (c-Fms; IC50 = 2 nM).{40050} It inhibits CSF1-dependent c-Fms phosphorylation in a dose-dependent manner in RAW264.7 cells and reduces CSF1-dependent growth of M-NFS-60 cells (IC50 = 14 nM). Ki20227 suppresses development of TRAP-positive osteoclast-like cells from murine bone marrow (IC50 = 40 nM) and decreases the number and area of osteolytic lesions on femurs and tibiae in a murine A375 subcutaneous xenograft model. Ki20227 also reduces TNF-α infiltration and osteolytic bone destruction in a collagen-induced arthritis (CIA) mouse model.{40051}  

 

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Description

A c-Fms kinase inhibitor (IC50 = 2 nM); inhibits CSF1-dependent c-Fms phosphorylation in a dose-dependent manner in RAW264.7 cells; reduces CSF1-dependent growth of M-NFS-60 cells (IC50 = 14 nM); suppresses development of TRAP-positive osteoclast-like cells from murine bone marrow (IC50 = 40 nM); decreases the number and area of osteolytic lesions on femurs and tibiae in a murine A375 subcutaneous xenograft model; reduces TNF-α infiltration and osteolytic bone destruction in a CIA mouse model,

Formal name: N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-methoxyphenyl]-N’-[1-(2-thiazolyl)ethyl]-urea

Synonyms: 

Molecular weight: 480.5

CAS: 623142-96-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Other Receptor Tyrosine Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer

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