A selective inhibitor of sAC with an IC50 value between 3-10 µM; decreases basal cAMP accumulation in sperm at 50 µM; used in diverse research applications including cAMP-mediated signaling events required for mammalian egg fertilization

KH7 – 5 mg

Brand:
Cayman
CAS:
330676-02-3
Storage:
-20
UN-No:
Non-Hazardous - 2811 / 6.1

Soluble adenylyl cyclase mediates bicarbonate-stimulated production of the ubiquitous second messenger adenosine 3’,5’-cyclic mononucleotide (cAMP).{17154} It is abundantly expressed in sperm, in fluid transporting tissues such as kidney cortex and medulla, and in other bicarbonate-responsive tissues and cells. KH7 is a selective inhibitor of soluble adenylyl cyclase (sAC) that has little effect on transmembrane adenylyl cyclases.{17005} It displays an IC50 value between 3-10 µM toward sAC.{17005} At 50 µM, KH7 decreases basal cAMP accumulation in sperm.{17005} KH7 has been used in diverse research applications including cAMP-mediated signaling events required for mammalian egg fertilization,{17005} sAC regulation of Na+ transport in the kidney,{17006} and mitochondrial-dependent apoptosis in response to various stress stimuli.{17155} KH7 is not active against sAC in the presence of detergents. At concentrations above 50 µM, KH7 exhibits non-specific membrane disruption effects when used on cells.  

 

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Description

A selective inhibitor of sAC with an IC50 value between 3-10 µM; decreases basal cAMP accumulation in sperm at 50 µM; used in diverse research applications including cAMP-mediated signaling events required for mammalian egg fertilization, sAC regulation of Na+ transport in the kidney, and mitochondrial-dependent apoptosis in response to various stress stimuli

Formal name: 2-(1H-benzimidazol-2-ylthio)-2-[(5-bromo-2-hydroxyphenyl)methylene]hydrazide, propanoic acid

Synonyms: 

Molecular weight: 419.3

CAS: 330676-02-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Cell Signaling|cAMP Signaling

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