An activator of p53; increases levels of activated p53 and expression of p21 in A549 cells and decreases expression of the transcription factor E2F1 in a variety of cell lines; decreases cell viability in a panel of cancer cell lines (mean IC50 = 0.49 μM); reduces tumor growth in various mouse xenograft models at 200 mg/kg

Kevetrin (hydrochloride) – 5 mg

Brand:
Cayman
CAS:
66592-89-0
Storage:
-20
UN-No:
Non-Hazardous - /

Kevetrin is an activator of p53.{47554,47555} It increases levels of activated p53 and expression of p21 in A549 cells and decreases expression of the transcription factor E2F1 in a variety of cell lines.{47554,47555} Kevetrin decreases cell viability in a panel of cancer cell lines with a mean IC50 value of 0.49 μM.{47556} It reduces tumor growth in MDA-MB-231, HT-29, PC3, HCT15, A549, NCI-H1975, CRL-1619, LNCaP, MIA PaCa, and SCC-5 mouse xenograft models when administered at a dose of 200 mg/kg.  

 

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SKU: 28288 - 5 mg Category:

Description

An activator of p53; increases levels of activated p53 and expression of p21 in A549 cells and decreases expression of the transcription factor E2F1 in a variety of cell lines; decreases cell viability in a panel of cancer cell lines (mean IC50 = 0.49 μM); reduces tumor growth in various mouse xenograft models at 200 mg/kg

Formal name: carbamimidothioic acid, 3-cyanopropyl ester, monohydrochloride

Synonyms:  4-Isothioureidobutyronitrile|NSC 525990

Molecular weight: 179.7

CAS: 66592-89-0

Purity: ≥95%

Formulation: A crystalline solid

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