An NSAID and COX inhibitor (IC50s = 20 nM for COX-1 and COX-2); prevents increases in paw swelling

Ketorolac (tromethamine salt) – 1 g

Brand:
Cayman
CAS:
74103-07-4
Storage:
22
UN-No:
- 2811 / 6.1

Ketorolac is a non-steroidal anti-inflammatory drug (NSAID) and a non-selective COX inhibitor (IC50 = 20 nM for both COX-1 and COX-2).{6065} It prevents increases in paw swelling, increases paw withdrawal latency in a hot-plate test, and decreases prostaglandin E2 (PGE2) levels in paw tissue in a mouse model of carrageenan-induced inflammation when administered at a dose of 30 mg/kg. Ketorolac is a racemic mixture containing the active (S)-ketorolac (Item No. 11348) and inactive (R)-ketorolac enantiomers. Formulations containing ketorolac have been used to manage postoperative pain and as ophthalmic solutions to treat ocular pain and inflammation.  

 

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SKU: 70690 - 1 g Category:

Description

An NSAID and COX inhibitor (IC50s = 20 nM for COX-1 and COX-2); prevents increases in paw swelling, increases paw withdrawal latency in a hot-plate test, and decreases PGE2 levels in paw tissue in a mouse model of carrageenan-induced inflammation at 30 mg/kg; a racemic mixture of the active (S)-ketorolac and inactive (R)-ketorolac enantiomers

Formal name: (±)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid, tris(hydroxymethyl)aminomethane salt

Synonyms:  Toradol

Molecular weight: 376.4

CAS: 74103-07-4

Purity: ≥99%

Formulation: A crystalline solid

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