An internal standard for the quantification of ketorolac by GC- or LC-MS

Ketorolac-d5 – 500 µg

Brand:
Cayman
CAS:
1215767-66-0
Storage:
-20
UN-No:
- 2811 / 6.1

Ketorolac-d5 is intended for use as an internal standard for the quantification of ketorolac (Item No. 9001148) by GC- or LC-MS. Ketorolac is a non-steroidal anti-inflammatory drug (NSAID) and a non-selective COX inhibitor (IC50 = 20 nM for both COX-1 and COX-2).{6065} It prevents increases in paw swelling, increases paw withdrawal latency in a hot-plate test, and decreases prostaglandin E2 (PGE2) levels in paw tissue in a mouse model of carrageenan-induced inflammation when administered at a dose of 30 mg/kg. Ketorolac is a racemic mixture containing the active (S)-ketorolac (Item No. 11348) and inactive (R)-ketorolac enantiomers. Formulations containing ketorolac have been used to manage postoperative pain and as ophthalmic solutions to treat ocular pain and inflammation.  

 

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SKU: 26454 - 500 µg Category:

Description

An internal standard for the quantification of ketorolac by GC- or LC-MS

Formal name: 5-(benzoyl-d5)-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid

Synonyms: 

Molecular weight: 260.3

CAS: 1215767-66-0

Purity: ≥99% deuterated forms (d1-d5)

Formulation: A solid

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Isotopically Labeled Standards|Deuterium||Product Type|Biochemicals|Small Molecule Inhibitors|Cyclooxygenases||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway||Research Area|Neuroscience|Ophthalmology||Research Area|Neuroscience|Pain Research

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