An NSAID and COX inhibitor (IC50 = 20 nM for both COX-1 and COX-2); prevents increases in paw swelling

Ketorolac (calcium salt) – 250 mg

Brand:
Cayman
CAS:
167105-81-9
Storage:
-20
UN-No:
Non-Hazardous - /

Ketorolac is a non-steroidal anti-inflammatory drug (NSAID) and a non-selective COX inhibitor (IC50 = 20 nM for both COX-1 and COX-2).{6065} It prevents increases in paw swelling, increases paw withdrawal latency in a hot-plate test, and decreases prostaglandin E2 (PGE2) levels in paw tissue in a mouse model of carrageenan-induced inflammation when administered at a dose of 30 mg/kg. Ketorolac is a racemic mixture containing the active (S)-ketorolac (Item No. 11348) and inactive (R)-ketorolac enantiomers. Formulations containing ketorolac have been used to manage postoperative pain and as ophthalmic solutions to treat ocular pain and inflammation.  

 

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SKU: 9003475 - 250 mg Category:

Description

An NSAID and COX inhibitor (IC50 = 20 nM for both COX-1 and COX-2); prevents increases in paw swelling, increases paw withdrawal latency in a hot-plate test, and decreases PGE2 levels in paw tissue in a mouse model of carrageenan-induced inflammation at 30 mg/kg; a racemic mixture of the active (S)-ketorolac and inactive (R)-ketorolac enantiomers

Formal name: 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid, hemicalcium salt

Synonyms: 

Molecular weight: 274.3

CAS: 167105-81-9

Purity: ≥98%

Formulation: A crystalline solid

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