An NSAID and COX inhibitor (IC50s = 20 nM for both COX-1 and COX-2); prevents increases in paw swelling

Ketorolac – 500 mg

Brand:
Cayman
CAS:
74103-06-3
Storage:
22
UN-No:
Non-Hazardous - 2811 / 6.1

Ketorolac is a non-steroidal anti-inflammatory drug (NSAID) and a non-selective COX inhibitor (IC50 = 20 nM for both COX-1 and COX-2).{6065} It prevents increases in paw swelling, increases paw withdrawal latency in a hot-plate test, and decreases prostaglandin E2 (PGE2) levels in paw tissue in a mouse model of carrageenan-induced inflammation when administered at a dose of 30 mg/kg. Ketorolac is a racemic mixture containing the active (S)-ketorolac (Item No. 11348) and inactive (R)-ketorolac enantiomers. Formulations containing ketorolac have been used to manage postoperative pain and as ophthalmic solutions to treat ocular pain and inflammation.  

 

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SKU: 9001148 - 500 mg Category:

Description

An NSAID and COX inhibitor (IC50s = 20 nM for both COX-1 and COX-2); prevents increases in paw swelling, increases paw withdrawal latency in a hot-plate test, and decreases PGE2 levels in paw tissue in a mouse model of carrageenan-induced inflammation at 30 mg/kg; a racemic mixture of the active (S)-ketorolac and inactive (R)-ketorolac enantiomers

Formal name: 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid

Synonyms:  RS 37619

Molecular weight: 255.3

CAS: 74103-06-3

Purity: ≥95%

Formulation: A crystalline solid

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