An internal standard for the quantification of ketoconazole by GC- or LC-MS

Ketoconazole-d3 – 500 µg

Brand:
Cayman
CAS:
1217766-70-5
Storage:
-20
UN-No:
- 2811 / 6.1

Ketoconazole-d3 is intended for use as an internal standard for the quantification of ketoconazole (Item No. 15212) by GC- or LC-MS. Ketoconazole is a broad-spectrum triazole antifungal agent that has activity against C. albicans, C. krusei, C. tropicalis, C. glabrata, C. parapsilosis, C. neoformans, and A. fumigatus strains (IC50s = 0.031-8 μg/ml).{24649} It inhibits the fungal cytochrome P450 (CYP) isoform CYP51, also known as lanosterol 14α-demethylase, which arrests ergosterol (Item No. 19850) biosynthesis at the fungal membrane. Ketoconazole also inhibits human CYP3A4 (IC50 = 0.54 μM). Formulations containing ketoconazole have been used in the treatment of fungal infections.  

 

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SKU: 10010656 - 500 µg Category:

Description

An internal standard for the quantification of ketoconazole by GC- or LC-MS

Formal name: 1-(4-(4-(((2R,4S)-2-((1H-imidazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazin-1-yl)ethan-1-one-2,2,2-d3

Synonyms: 

Molecular weight: 534.5

CAS: 1217766-70-5

Purity: ≥99% deuterated forms (d1-d3)

Formulation: A solid

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Antifungals|Triazoles||Product Type|Biochemicals|Isotopically Labeled Standards|Deuterium||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Fungal Diseases|Aspergillosis||Research Area|Infectious Disease|Fungal Diseases|Candidiasis||Research Area|Toxicology|Drug Metabolism|Cytochrome P450

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