A triazole antifungal agent; has activity against C. albicans

Ketoconazole – 500 mg

Brand:
Cayman
CAS:
65277-42-1
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Ketoconazole is a broad-spectrum triazole antifungal agent that has activity against C. albicans, C. krusei, C. tropicalis, C. glabrata, C. parapsilosis, C. neoformans, and A. fumigatus strains (IC50s = 0.031-8 µg/ml).{24649} It inhibits the fungal cytochrome P450 (CYP) isoform CYP51, also known as lanosterol 14α-demethylase, which arrests ergosterol (Item No. 19850) biosynthesis at the fungal membrane. Ketoconazole also inhibits human CYP3A4 (IC50 = 0.54 µM). Formulations containing ketoconazole have been used in the treatment of fungal infections.  

 

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Description

A triazole antifungal agent; has activity against C. albicans, C. krusei, C. tropicalis, C. glabrata, C. parapsilosis, C. neoformans, and A. fumigatus strains (IC50s = 0.031-8 µg/ml); inhibits fungal CYP51; inhibits human CYP3A4 (IC50 = 0.54 µM)

Formal name: 1-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]-ethanone

Synonyms:  R 41400

Molecular weight: 531.4

CAS: 65277-42-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antifungals|Triazoles||Product Type|Biochemicals|Small Molecule Inhibitors|Cytochrome P450||Product Type|Biochemicals|Small Molecule Inhibitors|Demethylases||Product Type|Biochemicals|Small Molecule Inhibitors|Sterol Biosynthesis||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Fungal Diseases|Aspergillosis||Research Area|Infectious Disease|Fungal Diseases|Candidiasis

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