An ATP-competitive inhibitor of several CDKs as well as GSK3β

Kenpaullone – 1 mg

Brand:
Cayman
CAS:
142273-20-9
Storage:
-20
UN-No:
Non-Hazardous - /

The development of selective, cell-permeable protein kinase inhibitors for the treatment of cancer, inflammation, and other diseases, is a major focus of drug development efforts. Kenpaullone is an ATP-competitive inhibitor of several cyclin-dependent kinases (CDKs) as well as glycogen synthase kinase 3β (GSK3β).{14993,14995,14994} It inhibits GSK3β with an IC50 value of 0.023 µM{14994} (0.23 µM){14995} and Cdk1/cyclin B, Cdk2/cyclin A, Cdk5/p25, and lymphocyte kinase with IC50 values of 0.4, 0.68, 0.85, and 0.47 µM, respectively.{14993}  

 

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SKU: 10010239 - 1 mg Category:

Description

An ATP-competitive inhibitor of several CDKs as well as GSK3β

Formal name: 9-bromo-7,12-dihydro-indolo[3,2-d][1]benzazepin-6(5H)-one

Synonyms:  9-Bromopaullone|NSC 664704

Molecular weight: 327.2

CAS: 142273-20-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|CDKs||Product Type|Biochemicals|Kinase Inhibitors|GSK3||Product Type|Biochemicals|Kinase Inhibitors|SRC Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Cycle

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