A mercaptoketone-based inhibitor of class I and II HDACs (IC50s = 20

KD 5170 – 1 mg

Brand:
Cayman
CAS:
940943-37-3
Storage:
-20
UN-No:
Non-Hazardous - /

KD 5170 is a mercaptoketone-based inhibitor of class I and II histone deacetylases (HDACs; IC50s = 20, 2,060, 75, 26, 950, 14, 85, 2,500, 150, and 18 nM for HDAC1-10, respectively).{33761} It exhibits broad spectrum antitumor activity in vitro and in vivo.{33761,33760,16850} KD 5170 increases the acetylation of histones and activates caspases 3, 8, and 9, leading to apoptosis in primary myeloma cells.{33760}  

 

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Description

A mercaptoketone-based inhibitor of class I and II HDACs (IC50s = 20, 2,060, 75, 26, 950, 14, 85, 2,500, 150, and 18 nM for HDAC1-10, respectively); exhibits broad spectrum antitumor activity in vitro and in vivo

Formal name: ethanethioic acid S-[2-[6-[[[4-[3-(dimethylamino)propoxy]phenyl]sulfonyl]amino]-3-pyridinyl]-2-oxoethyl] ester

Synonyms: 

Molecular weight: 451.6

CAS: 940943-37-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Deacetylases||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Epigenetics, Transcription, & Translation|Erasers|Histone Deacetylation

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