An inhibitor of HIF-1α protein translation; suppresses phosphorylation of two key regulators of protein synthesis

KC7F2 – 5 mg

Brand:
Cayman
CAS:
927822-86-4
Storage:
-20
UN-No:
Non-Hazardous - /

Hypoxia-inducible factor-1 (HIF-1) is a heterodimeric transcription factor composed of a HIF-1α subunit and HIF-1β subunit. The HIF-1α subunit is regulated by cellular oxygen levels and therefore plays an important role in maintaining cellular oxygen homeostasis.{11044,12428} KC7F2 is an inhibitor of HIF-1α protein translation, but not transcription, that suppresses phosphorylation of two key regulators of protein synthesis, eukaryotic translation initiation factor 4E binding protein 1 (4EBP1) and p70 S6 kinase (S6K).{23550} It inhibits hypoxia-induced expression of several HIF target genes, such as carbonic anhydrase IX, matrix metalloproteinase 2, enolase 1, and endothelin 1. KC7F2 is cytotoxic to a variety of cancer cell lines with an IC50 value of 15-25 µM.{23550}  

 

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Description

An inhibitor of HIF-1α protein translation; suppresses phosphorylation of two key regulators of protein synthesis, eukaryotic translation initiation factor 4E binding protein 1 (4EBP1) and p70 S6 kinase; cytotoxic to a variety of cancer cell lines with an IC50 value of 15-25 µM

Formal name: N,N’-(dithiodi-2,1-ethanediyl)bis[2,5-dichloro-benzenesulfonamide

Synonyms: 

Molecular weight: 570.4

CAS: 927822-86-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Prolyl Hydroxylation Enzymes||Research Area|Cancer|Cell Death||Research Area|Cancer|Transcription Factors|HIF-1α||Research Area|Cancer|Tumor Microenvironment||Research Area|Cell Biology|Cell Signaling||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors

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