A covalent inhibitor of ABHD16A (IC50s = 90 and 520 nM for human and mouse

KC01 – 500 µg

Brand:
Cayman
CAS:
1646795-59-6
Storage:
-20
UN-No:
Non-Hazardous - /

ABHD16A (also known as HLA-B associated transcript 5 (BAT5)) is a phosphatidylserine hydrolase that regulates the formation of lysophosphatidylserines (lyso-PSs) and has been implicated in certain immunological and neurological diseases.{28160} KC01 is a covalent inhibitor of ABHD16A (IC50s = 90 and 520 nM for human and mouse, respectively).{28160} It has been shown to deplete lyso-PS from various human cancer cell lines, a lymphoblast cell line, and mouse brain membrane lysates and to decrease LPS-induced cytokine production in macrophages.{28160} This compound has been used to characterize the role of ABHD16A as a principle phosphatidylserine lipase in vivo.{28160}  

 

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Description

A covalent inhibitor of ABHD16A (IC50s = 90 and 520 nM for human and mouse, respectively); depletes lyso-PS from various human cancer cell lines, a lymphoblast cell line, and mouse brain membrane lysates and decreases LPS-induced cytokine production in macrophages

Formal name: 6Z-(2-oxo-4-tridecyl-3-oxetanylidene), hexanamide

Synonyms: 

Molecular weight: 365.6

CAS: 1646795-59-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Lipid Biochemistry||Research Area|Neuroscience

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