A synthetic analog of α-GalCer; induces IL-4 and IFN-γ secretion by mouse at 0.5 ng/ml; induces IL-2 secretion by DN32.D3 NKT hybridoma cells co-cultured with CD1d-transfected RBL cells pre-loaded with KBC-007 at 8 ng/ml; increases levels of IL-4

KBC-007 – 50 µg

Brand:
Cayman
CAS:
1037297-61-2
Storage:
-20
UN-No:
Non-Hazardous - /

KBC-007 is a synthetic branched chain-containing analog of α-galactosylceramide (α-GalCer).{46100,46099} It induces IL-4 and IFN-γ secretion by mouse splenocytes when used at a concentration of 0.5 ng/ml and IL-2 secretion by DN32.D3 NKT hybridoma cells co-cultured with CD1d-transfected RBL cells pre-loaded with KBC-007 at a concentration of 8 ng/ml.{46100} KBC-007 (1 μg per animal) increases levels of IL-4, but not IFN-γ, to a similar degree as α-GalCer in mouse serum. KBC-007 (0.5 μg per animal) increases the survival rate of mice immunized with the inactivated influenza A virus A/PR/8/34 in a model of influenza infection. {46099}  

 

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SKU: 26661 - 50 µg Category:

Description

A synthetic analog of α-GalCer; induces IL-4 and IFN-γ secretion by mouse at 0.5 ng/ml; induces IL-2 secretion by DN32.D3 NKT hybridoma cells co-cultured with CD1d-transfected RBL cells pre-loaded with KBC-007 at 8 ng/ml; increases levels of IL-4, but not IFN-γ, to a similar degree as α-GalCer in mouse serum at 1 μg per animal; increases the survival rate of mice immunized with the inactivated influenza A virus A/PR/8/34 in a model of influenza infection at 0.5 μg per animal

Formal name: 8-(diheptylamino)-N-[(1S,2S,3R)-1-[(α-D-galactopyranosyloxy)methyl]-2,3-dihydroxyheptadecyl]-octanamide

Synonyms: 

Molecular weight: 817.2

CAS: 1037297-61-2

Purity: ≥95%

Formulation: An oil

Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Lipids|Sphingolipids||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Infectious Disease|Viral Diseases|Influenza||Research Area|Lipid Biochemistry|Sphingolipids

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