A bacterial metabolite; has antifungal activity against S. pombe and R. javanicus (MICs = 0.05 and 2.13 µg/ml

Kazusamycin B – 500 µg

Brand:
Cayman
CAS:
107140-30-7
Storage:
-20
UN-No:
Non-Hazardous - /

Kazusamycin B is a bacterial metabolite originally isolated from Streptomyces.{47374} It has antifungal activity against S. pombe and R. javanicus (MICs = 0.05 and 2.13 µg/ml, respectively) but is inactive against Gram-positive and Gram-negative bacteria (MICs = >100 µg/ml). Kazusamycin B (5 ng/ml) halts the cell cycle at the G1 phase and induces nuclear condensation in L1210 cells, as well as inhibits nuclear-to-cytosolic transport of the HIV-1 regulatory protein Rev in HeLa cells expressing Rev (IC50 = 6.3 nM).{47375,31690} It is cytotoxic to L1210 and HCT-8 cells with IC50 values of 1.8 and 1.6 ng/ml, respectively, and reduces tumor growth in a variety of murine tumor and mouse xenograft models.{47376}  

 

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SKU: 28119 - 500 µg Category:

Description

A bacterial metabolite; has antifungal activity against S. pombe and R. javanicus (MICs = 0.05 and 2.13 µg/ml, respectively); halts the cell cycle at the G1 phase and induces nuclear condensation in L1210 cells at 5 ng/ml; inhibits nuclear-to-cytosolic transport of Rev in HeLa cells expressing Rev (IC50 = 6.3 nM); cytotoxic to L1210 and HCT-8 cells (IC50 = 1.8 and 1.6 ng/ml, respectively); reduces tumor growth in a variety of murine tumor and mouse xenograft models

Formal name: (2E,10E,12E,16Z,18E)-19-(3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-6-hydroxy-9-(hydroxymethyl)-3,5,7,11,15,17-hexamethyl-8-oxo-2,10,12,16,18-nonadecapentaenoic acid

Synonyms:  CL 1957E|Hydroxyleptomycin A|PD 124895

Molecular weight: 542.7

CAS: 107140-30-7

Purity: ≥95%

Formulation: A film

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