An antitumor antibiotic that inhibits nuclear export and translocation of Rev

Kazusamycin A – 100 µg

Brand:
Cayman
CAS:
92090-94-3
Storage:
-20
UN-No:
Non-Hazardous - /

Kazusamycin A is an antibiotic from Streptomyces and a hydroxy analog of Leptomycin B (Item No. 10004976) that demonstrates cytotoxic activity against various human and mouse tumor lines.{31688} Additionally, at nanomolar concentrations, it inhibits nuclear export and translocation of Rev, a regulatory gene product in the HIV genome.{31689,31690}  

 

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SKU: 20137 - Category:

Description

An antitumor antibiotic that inhibits nuclear export and translocation of Rev, a regulatory gene product in the HIV genome

Formal name: (2E,5S,6R,7S,9S,10E,12E,15R,16Z,18E)-19-[(2S,3S)-3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl]-17-ethyl-6-hydroxy-9-(hydroxymethyl)-3,5,7,11,15-pentamethyl-8-oxo-2,10,12,16,18-nonadecapentaenoic acid

Synonyms:  CL 1,957B|Hydroxyelactocin|Hydroxyleptomycin B|PD 114721

Molecular weight: 556.7

CAS: 92090-94-3

Purity: ≥95%

Formulation: A film

Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Research Area|Cancer||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|HIV & AIDS

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