A kavalactone with diverse biological activities; a positive allosteric modulator of α4β2δ subunit-containing GABAA receptors (EC50s = 25 and 59 µM in the presence and absence of 300 µM kavain); reduces growth of WPMY-1 prostate cancer cells (IC50= 5.2 µg/ml); reduces LPS-induced TNF-α production in primary murine macrophages; reduces hind paw swelling and TNF-α production in a mouse model of collagen-induced arthritis; reduces acetic acid-induced abdominal constrictions in mice (ED50= 15.71 mg/kg)

Kavain – 10 mg

Brand:
Cayman
CAS:
500-64-1
Storage:
-20
UN-No:
Non-Hazardous - /

Kavain is a kavalactone and the major constituent of the pepper plant kava (P. methysticum) and has diverse biological activities.{46119,46120,46121,46122} It is a positive allosteric modulator of α4β2δ subunit-containing GABAA receptors with EC50 values of 25 and 59 µM in the presence and absence of 300 µM kavain, respectively, in Xenopus oocytes expressing human receptors.{46119} Kavain reduces growth of WPMY-1 prostate cancer cells (IC50 = 5.2 µg/ml).{46120} It reduces LPS-induced TNF-α production in primary murine macrophages in a concentration-dependent manner.{46121} In vivo, kavain (1 mg/animal) reduces hind paw swelling and TNF-α production in wild-type, but not Erk-/-, mice in a mouse model of collagen-induced arthritis. Kavain also reduces acetic acid-induced abdominal constrictions in mice (ED50= 15.71 mg/kg).{46122}  

 

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SKU: 26524 - 10 mg Category:

Description

A kavalactone with diverse biological activities; a positive allosteric modulator of α4β2δ subunit-containing GABAA receptors (EC50s = 25 and 59 µM in the presence and absence of 300 µM kavain); reduces growth of WPMY-1 prostate cancer cells (IC50= 5.2 µg/ml); reduces LPS-induced TNF-α production in primary murine macrophages; reduces hind paw swelling and TNF-α production in a mouse model of collagen-induced arthritis; reduces acetic acid-induced abdominal constrictions in mice (ED50= 15.71 mg/kg)

Formal name: (6R)-5,6-dihydro-4-methoxy-6-[(1E)-2-phenylethenyl]-2H-pyran-2-one

Synonyms:  Kawain|NSC 112162

Molecular weight: 230.3

CAS: 500-64-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation||Product Type|Biochemicals|Natural Products||Research Area|Cancer||Research Area|Immunology & Inflammation|Autoimmunity|Rheumatoid Arthritis||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Neuroscience|Pain Research

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