A diterpene with diverse biological activities; cytotoxic to a variety of prostate

Kaurenoic Acid – 10 mg

Brand:
Cayman
CAS:
6730-83-2
Storage:
-20
UN-No:
Non-Hazardous - /

Kaurenoic acid is a diterpene that has been found in C. langsdorffii and has diverse biological activities, including anticancer, antibacterial, antioxidant, and anti-inflammatory properties.{48636,48637,48638} It is cytotoxic to 22Rv1 and LNCaP prostate, HT-29, HCT116, SW480, and SW620 colon, and MCF-7 breast cancer cells with IC50 values ranging from 15.03 to 48.87 μg/ml.{48637} Kaurenoic acid is active against S. epidermidis, S. capitis, E. faecalis, and S. haemolyticus in vitro (MICs = 6.25-12.5 μg/ml).{48638} Kaurenoic acid (50 and 100 mg/kg) reduces colonic myeloperoxidase (MPO) activity and malondialdehyde (MDA) levels in a rat model of acetic acid-induced colitis, as well as colonic tissue damage, leukocytic infiltration, and submucosal edema when administered at a dose of 100 mg/kg.{48636}  

 

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SKU: 28957 - 10 mg Category:

Description

A diterpene with diverse biological activities; cytotoxic to a variety of prostate, colon, and breast cancer cells (IC50s = 15.03-48.87 μg/ml); active against S. epidermidis, S. capitis, E. faecalis, and S. haemolyticus in vitro (MICs = 6.25-12.5 μg/ml); reduces colonic MPO activity and MDA levels in a rat model of acetic acid-induced colitis at 50 and 100 mg/kg, as well as colonic tissue damage, leukocytic infiltration, and submucosal edema when administered at a dose of 100 mg/kg

Formal name: (4α)-kaur-16-en-18-oic acid

Synonyms: 

Molecular weight: 302.5

CAS: 6730-83-2

Purity: ≥98%

Formulation: A solid

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