A potent inducer of chondrocyte differentiation from human mesenchymal stem cells (EC50 = 100 nM); promotes cartilage repair in a mouse model of osteoarthritis and protects against cytokine-induced damage in osteoarthritic bovine articular chondrocytes in vitro

Kartogenin – 25 mg

Brand:
Cayman
CAS:
4727-31-5
Storage:
-20
UN-No:
De Minimis - 3077 / 9

Kartogenin potently induces differentiation of human mesenchymal stem cells into chondrocytes with an EC50 value of 100 nM.{20986} Kartogenin induces chondrogenesis by binding the actin-binding protein, filamin A, which disrupts its interaction with the transcription factor core-binding factor β subunit (CBFβ). When dissociated from filamin A, CBFβ translocates to the nucleus and forms a transcriptional complex with the runt-related transcription factor RUNX1, which enables chondrocyte differentiation. Kartogenin has been shown to promote cartilage repair in a mouse model of osteoarthritis and to protect against cytokine-induced damage in osteoarthritic bovine articular chondrocytes in vitro.{20986}  

 

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SKU: 11826 - 25 mg Category:

Description

A potent inducer of chondrocyte differentiation from human mesenchymal stem cells (EC50 = 100 nM); promotes cartilage repair in a mouse model of osteoarthritis and protects against cytokine-induced damage in osteoarthritic bovine articular chondrocytes in vitro

Formal name: 2-[([1,1’-biphenyl]-4-ylamino)carbonyl]-benzoic acid

Synonyms: 

Molecular weight: 317.3

CAS: 4727-31-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cell Biology|Cytoskeleton & Motor Proteins||Research Area|Cell Biology|Stem Cell Research|Differentiation||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Immunology & Inflammation|Arthritis (Non-autoimmune)

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