A natural diterpene that increases glutathione S-transferase expression and activity in vivo; inhibits LPS-induced NO and PGE2 production (IC50 = 54 and 23 μM

Kahweol – 5 mg

Brand:
Cayman
CAS:
6894-43-5
Storage:
-20
UN-No:
Non-Hazardous - /

Kahweol is a natural diterpene that is isolated from coffee beans.{21876} It increases glutathione S-transferase activity in the gut mucosa of mice and, with the diterpene cafestol, induces glutathione S-transferase expression in rat livers.{21876,21874} Kahweol has anti-inflammatory effects in RAW macrophages, inhibiting LPS-induced nitric oxide and prostaglandin E2 production (IC50 = 54 and 23 μM, respectively).{21878} Kahweol also is antiangiogenic, blocking the proliferation of endothelial cells (IC50 = 50 μM) and inhibiting endothelial migration, invasion, and tube formation.{21873} Kahweol is easily oxidized in the presence of air.{21876}  

 

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Description

A natural diterpene that increases glutathione S-transferase expression and activity in vivo; inhibits LPS-induced NO and PGE2 production (IC50 = 54 and 23 μM, respectively) in RAW macrophages; blocks the proliferation of endothelial cells (IC50 = 50 μM) and inhibits endothelial migration, invasion, and tube formation

Formal name: 3bS,4,5,6,7R,8R,9,10,10aR,10bS-decahydro-7-hydroxy-10b-methyl-5aS,8-methano-5aH-cyclohepta[5,6]naphtho[2,1-b]furan-7-methanol

Synonyms: 

Molecular weight: 314.4

CAS: 6894-43-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Terpenes||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Immunology & Inflammation|Innate Immunity

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