A flavonoid with diverse biological activities; scavenges DPPH radicals in a cell-free assay (IC50 = 97.58 μg/ml); cytotoxic to HT-1080 and Colon 26-L5 cells (EC50s = 2.91 and 5.95 μg/ml

Kaempferide – 50 mg

Brand:
Cayman
CAS:
491-54-3
Storage:
-20
UN-No:
Non-Hazardous - /

Kaempferide is a flavonoid that has been found in Alpinia and has diverse biological activities.{46690,46691,46692,46693} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in a cell-free assay (IC50 = 97.58 μg/ml).{46690} Kaempferide is cytotoxic to HT-1080 and Colon 26-L5 cells (EC50s = 2.91 and 5.95 μg/ml, respectively) and decreases lipid accumulation in 3T3-L1 preadipocytes when used at a concentration of 50 μM.{46691,46692} It attenuates decreases in left ventricular systolic pressure (LVSP) and increases in left ventricular end-diastolic pressure (LVEDP) and reduces infarct size in a rat model of myocardial ischemia-reperfusion injury induced by coronary artery ligation when administered at doses of 0.3 and 1 mg/kg.{46693}  

 

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Description

A flavonoid with diverse biological activities; scavenges DPPH radicals in a cell-free assay (IC50 = 97.58 μg/ml); cytotoxic to HT-1080 and Colon 26-L5 cells (EC50s = 2.91 and 5.95 μg/ml, respectively); decreases lipid accumulation in 3T3-L1 preadipocytes at 50 μM; attenuates decreases in LVSP and increases in LVEDP and reduces infarct size in a rat model of myocardial ischemia-reperfusion injury induced by coronary artery ligation at 0.3 and 1 mg/kg

Formal name: 3,5,7-trihydroxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one

Synonyms:  3,5,7-Trihydroxy-4′-methoxyflavone|4′-O-Methylkaempferol

Molecular weight: 300.3

CAS: 491-54-3

Purity: ≥95%

Formulation: A solid

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