A cell-permeable PKC inhibitor (IC50s = 2.45 and 25.7 µM for PKC and PKA

K252c – 10 mg

Brand:
Cayman
CAS:
85753-43-1
Storage:
-20
UN-No:
Non-Hazardous - /

K252c is a cell-permeable PKC inhibitor (IC50s = 2.45 and 25.7 µM for PKC and PKA, respectively).{34152} It induces apoptosis in human chronic myelogenous leukemia cancer cells.{34151} In human foreskin fibroblast cells, it reduces focus formation induced by human cytomegalovirus (HCMV) strains sensitive and resistant to Ganciclovir (Item No. 13853) with IC50s of 0.32 and 0.17 µM for HCMV A6245 and HCMV-6, respectively.{34153} It also inhibits the non-kinase enzymes β-lactamase, chymotrypsin, and malate dehydrogenase with IC50s of 8, 10, and 8 µM, suggesting less kinase-selectivity than was originally described.{22472}  

 

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Description

A cell-permeable PKC inhibitor (IC50s = 2.45 and 25.7 µM for PKC and PKA, respectively); reduces focus formation in gangciclovir-sensitive and -resistant human cytomegalovirus (HCMV) strains with IC50s of 0.32 and 0.17 µM for HCMV A6245 and HCMV-6, respectively; inhibits the non-kinase enzymes β-lactamase, chymotrypsin, and malate dehydrogenase with IC50s of 8, 10, and 8 µM

Formal name: 6,7,12,13-tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one

Synonyms:  SD 1825|Staurosporine aglycone

Molecular weight: 311.3

CAS: 85753-43-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Kinase Inhibitors|PKC||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|PKC Signaling||Research Area|Cell Biology|Proteolysis|Cytosolic & Secreted Proteases||Research Area|Infectious Disease|Viral Diseases

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