A cell-impermeable kinase inhibitor

K252b – 500 µg

Brand:
Cayman
CAS:
99570-78-2
Storage:
-20
UN-No:
Non-Hazardous - /

K252b is an indolocarbazole isolated from the actinomycete Nocardiopsis, first described as an inhibitor of protein kinase C.{21294} However, as this compound does not freely pass through the cell membrane, it is used to inhibit extracellular kinases (ectokinases) of cells in culture.{21291,21295} K252b inhibits receptor-mediated degranulation from basophil-like RBL-2H3 cells (IC50 = 0.5 μg/ml) and human basophils.{21292} This extracellular inhibitor is also used in comparison studies with the closely related, cell-permeable inhibitor K252a, particularly in studies of neuronal differentiation.{21293,21290}  

 

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SKU: 11339 - 500 µg Category:

Description

A cell-impermeable kinase inhibitor, first described as an inhibitor of PKC; used to inhibit extracellular kinases (ectokinases) of cells in culture; inhibits receptor-mediated degranulation from RBL-2H3 cells (IC50 = 0.5 μg/ml); also used in comparison studies with the cell-permeable inhibitor K252a

Formal name: (9S,10R,12R)-2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3′,2′,1′-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid

Synonyms: 

Molecular weight: 453.5

CAS: 99570-78-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Immunology & Inflammation|Allergy||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Neuroscience

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