A DNA alkylating agent; increases the concentration of O6-methylated deoxyguanosine in U87 GBM cells in a concentration-dependent manner; reduces cell viability in GBM cell lines lacking (IC50s = 18-44 μM) or expressing MGMT (IC50s = 115-240 μM); can cross the blood-brain barrier; increases survival in a Br23c mouse xenograft model of GBM at 14.9 mg/kg

K-TMZ – 5 mg

Brand:
Cayman
CAS:
2269482-26-8
Storage:
-20
UN-No:
Excepted Quantity - 1231 / 3

K-TMZ is a DNA alkylating agent.{42788} It increases the concentration of O6-methylated deoxyguanosine in U87 glioblastoma multiforme (GBM) cells in a concentration-dependent manner. K-TMZ reduces cell viability of GBM cell lines lacking (IC50s = 18-44 μM) or expressing O6-methylguanine DNA methyltransferase (MGMT; IC50s = 115-240 μM). K-TMZ can cross the blood-brain barrier and increases survival in a Br23c mouse xenograft model of GBM when administered at a dose of 14.9 mg/kg.  

 

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SKU: 27022 - 5 mg Category:

Description

A DNA alkylating agent; increases the concentration of O6-methylated deoxyguanosine in U87 GBM cells in a concentration-dependent manner; reduces cell viability in GBM cell lines lacking (IC50s = 18-44 μM) or expressing MGMT (IC50s = 115-240 μM); can cross the blood-brain barrier; increases survival in a Br23c mouse xenograft model of GBM at 14.9 mg/kg ,

Formal name: 8-acetyl-3-methyl-imidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one

Synonyms: 

Molecular weight: 193.2

CAS: 2269482-26-8

Purity: ≥95%

Formulation: A solution in methyl acetate

Product Type|Biochemicals|DNA Alkylating Agents||Research Area|Cancer|Cell Death||Research Area|Cancer|DNA Damage and Repair|DNA Alkylating Agents

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