A fungal metabolite with antibiotic and antiparasitic activities; active against B. subtilis

K-41 – 1 mg

Brand:
Cayman
CAS:
53026-37-2
Storage:
-20
UN-No:
Non-Hazardous - /

K-41 is a monoglycoside polyether fungal metabolite originally isolated from S. hygroscopicus that has antibiotic and antiparasitic activities.{49629,29573} It is active against B. subtilis, B. anthracis, S. aureus, S. pyogenes, S. pneumoniae, C. diphtheriae, and M. tuberculosis (MICs = 3.13, 1.56, 1.56, 0.78, 0.39, 0.78, and 3.13 µg/ml, respectively).{49629} K-41 is active against the K1 drug-resistant and FCR3 drug-susceptible P. falciparum strains (IC50s = 8.5 and 31 nM, respectively).{29573} In vivo, K-41 has antiparasitic activity in mouse models of P. berghei and P. yoelii infection (ED50s = 1.9 and 7.0 mg/kg, respectively).  

 

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SKU: 29573 - 1 mg Category:

Description

A fungal metabolite with antibiotic and antiparasitic activities; active against B. subtilis, B. anthracis, S. aureus, S. pyogenes, S. pneumoniae, C. diphtheriae, and M. tuberculosis (MICs = 3.13, 1.56, 1.56, 0.78, 0.39, 0.78, and 3.13 µg/ml, respectively); active against the K1 drug-resistant and FCR3 drug-susceptible P. falciparum strains (IC50s = 8.5 and 31 nM, respectively); has antiparasitic activity in mouse models of P. berghei and P. yoelii infection (ED50s = 1.9 and 7.0 mg/kg, respectively)

Formal name: (29S)-9,13:17,20:21,24-trianhydro-4,8,10,12,14,18,19,22,23,26,28,30-dodecadeoxy-4,12,14,26,28-pentamethyl-6,16-di-C-methyl-5,6,11,15-tetra-O-methyl-27-O-[(2R,5S,6R)-tetrahydro-5-methoxy-6-methyl-2H-pyran-2-yl]-L-xylo-L-manno-α-D-gluco-L-ribo-α-L-gluco-D-glycero-3,13,29-triacontotriulo-13,16-furanose-3,7:29,25-dipyranosonic acid

Synonyms: 

Molecular weight: 947.2

CAS: 53026-37-2

Purity: ≥70%

Formulation: A solid

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