A potent inhibitor of both FAAH and MAGL (IC50s = 2 and 4 nM

JZL 195 – 100 mg

Brand:
Cayman
CAS:
1210004-12-8
Storage:
-20
UN-No:
De Minimis - 3077 / 9

Fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) mediate the hydrolysis of the endocannabinoids arachidonoyl ethanolamide (AEA) and 2-arachidonoylglycerol (2-AG), respectively. JZL 195 is a potent inhibitor of both FAAH and MAGL (IC50s = 2 and 4 nM, respectively).{17764} It poorly inhibits neuropathy target esterase and ABHD6 and does not inhibit other brain serine hydrolases. JZL 195 displays time-dependent inhibition of FAAH and MAGL in vivo, consistent with a covalent mechanism of activation.{17764} The in vivo inhibitory actions of JZL 195 against FAAH and MAGL are comparable to those of the selective inhibitors PF-3845 (Item No. 13279) and JZL 184 (Item No. 13158), respectively.{17764} Through its inhibitory actions, JZL 195 simultaneously augments brain levels of AEA and 2-AG, producing antinociceptive, cataleptic, and hypomotility effects like those produced by direct CB1 agonists.{17764}  

 

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Description

A potent inhibitor of both FAAH and MAGL (IC50s = 2 and 4 nM, respectively); poorly inhibits other brain serine hydrolases

Formal name: 4-nitrophenyl 4-(3-phenoxybenzyl)piperazine-1-carboxylate

Synonyms: 

Molecular weight: 433.5

CAS: 1210004-12-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Fatty Acid Metabolism||Product Type|Biochemicals|Small Molecule Inhibitors|Glycerolipid Lipases||Research Area|Neuroscience|Cannabinoid Research|Endocannabinoids||Research Area|Neuroscience|Pain Research

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