An inhibitor of NF-κB

JSH-23 – 1 mg

Brand:
Cayman
CAS:
749886-87-1
Storage:
-20
UN-No:
Non-Hazardous - /

JSH-23 is an inhibitor of NF-κB, blocking its translocation into the nucleus (IC50 = 7.1 µM).{24719} It does not affect degradation of the inhibitor of NF-κB, IκB.{24719} JSH-23 interferes with NF-κB-mediated gene expression and apoptosis in RAW 264.7 cells treated with lipopolysaccharide.{24719} It has also been used to investigate the roles of NF-κB in cancer, inflammation, and neurogenesis.{24722,24720,24721}  

 

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Description

An inhibitor of NF-κB, blocking its translocation into the nucleus (IC50 = 7.1 µM); does not affect degradation of IκB; interferes with NF-κB-mediated gene expression and apoptosis in RAW 264.7 cells treated with LPS

Formal name: 4-methyl-N1-(3-phenylpropyl)-1,2-benzenediamine

Synonyms:  NF-κB Activation Inhibitor II

Molecular weight: 240.3

CAS: 749886-87-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|TNF-α/NF-κB Signaling||Research Area|Cancer|Cell Signaling|NF-κB Signaling||Research Area|Cancer|Transcription Factors|NF-κB||Research Area|Cell Biology|Cell Signaling|NF-κB Signaling||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Immunology & Inflammation|Autoimmunity||Research Area|Immunology & Inflammation|Innate Immunity|Pattern Recognition||Research Area|Immunology & Inflammation|Innate Immunity|STING||Research Area|Infectious Disease||Research Area|Neuroscience

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