A nitric oxide donor; inhibits proliferation of HL-60 cells (IC50 = 0.5 µM); decreases tumor volume by over 50% in an HL-60 mouse xenograft model when used at a dose of 4 µmol/kg

JS-K – 5 mg

Brand:
Cayman
CAS:
205432-12-8
Storage:
-20
UN-No:
Non-Hazardous - /

JS-K is a nitric oxide (NO) donor that reacts with glutathione to generate NO at physiological pH.{38457} It inhibits proliferation of HL-60 cells (IC50 = 0.5 µM), which is prevented by the glutathione precursor N-acetyl-L-cysteine (Item No. 20261), and inhibits growth of the solid tumor cell lines PPC-1, DLD-1, and Meth A. It decreases tumor volume by over 50% in an HL-60 mouse xenograft model when used at a dose of 4 µmol/kg, i.v., three times per week. JS-K inhibits proliferation, induces apoptosis, and disrupts the cell cycle of Jurkat T acute lymphoblastic leukemia cells.{38456} It also induces S-nitrosylation of β-catenin followed by dose-dependent degradation of nuclear β-catenin and S-nitrosylated nuclear β-catenin levels.  

 

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Description

A nitric oxide donor; inhibits proliferation of HL-60 cells (IC50 = 0.5 µM); decreases tumor volume by over 50% in an HL-60 mouse xenograft model when used at a dose of 4 µmol/kg, i.v.; induces S-nitrosylation of β-catenin followed by dose-dependent degradation of nuclear β-catenin and S-nitrosylated nuclear β-catenin levels

Formal name: 4-[2-(2,4-dinitrophenoxy)-1-oxidodiazenyl]-1-piperazinecarboxylic acid, ethyl ester

Synonyms: 

Molecular weight: 384.3

CAS: 205432-12-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ox Stress Reagents|NO Donors||Research Area|Cancer|Cell Cycle||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|Nitric Oxide Signaling||Research Area|Cancer|Cell Signaling|Wnt Signaling||Research Area|Cancer|DNA Damage and Repair||Research Area|Oxidative Stress & Reactive Species|Reactive Nitrogen||Research Area|Oxidative Stress & Reactive Species|Reactive Sulfur|Glutathione

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