(+)-JQ1 (free acid) – 5 mg

Brand:
Cayman
CAS:
202592-23-2
Storage:
-20
UN-No:
Non-Hazardous - /

(+)-JQ1 (free acid) is an inhibitor of bromodomain and extra terminal domain (BET) family proteins (Kds = 128, 59.5, 49.0, and 190 nM for JQ1 binding to bromodomains of BRD2, BRD3, BRD4, and BRDT, respectively), blocking their interaction with acetylated histones.{19044,28490} Enantiomerically pure (+)-JQ1 (Item No. 11187) binds to BRD4 bromodomains 1 and 2 with Kd values of ~50 and 90 nM, respectively, whereas the (−)-JQ1 (Item No. 11232) stereoisomer has no appreciable affinity to BET bromodomains.{19044} JQ1 has been used as a chemical probe to investigate the role of BET bromodomains in the transcriptional regulation of oncogenesis.{19044,28490,20263,20272,20182} See the Structural Genomics Consortium (SGC) website for more information.  

 

Available on backorder

SKU: 9002910 - 5 mg Category:

Description

An inhibitor of BET family proteins; binds to BRD4 bromodomains 1 and 2 with Kd values of ~50 and 90 nM, respectively


Formal name: (6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid

Synonyms: 

Molecular weight: 400.9

CAS: 202592-23-2

Purity: ≥98%

Formulation: A crystalline solid