An irreversible FAAH inhibitor of the carbamate class with an IC50 value of 7.3 nM for the human recombinant enzyme when tested using radiolabeled oleamide as the substrate; the alkyl derivative on JP104 reacts with azide-modified reporter tags

JP104 – 50 mg

Brand:
Cayman
CAS:
887264-45-1
Storage:
-20
UN-No:
Non-Hazardous - /

The enzyme, fatty acid amide hydrolase (FAAH), is widely expressed in brain and other tissues, and is capable of hydrolyzing anandamide (AEA) and other simple esters and amides with long unsaturated acyl chains.{3110} JP104 is an irreversible fatty acid amide hydrolase (FAAH) inhibitor of the carbamate class with an IC50 of 7.3 nM for the human recombinant enzyme when tested using radiolabeled oleamide as the substrate.{14130} The alkyl derivative on JP104 reacts with azide-modified reporter tags, such as azido-rhodamine or azido-biotin, for visualization of JP104 bound to FAAH in vivo.  

 

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SKU: 10008661 - 50 mg Category:

Description

An irreversible FAAH inhibitor of the carbamate class with an IC50 value of 7.3 nM for the human recombinant enzyme when tested using radiolabeled oleamide as the substrate; the alkyl derivative on JP104 reacts with azide-modified reporter tags, such as azido-rhodamine or azido-biotin, for visualization of JP104 bound to FAAH in vivo

Formal name: N-10-undecyn-1-yl-carbamic acid, 3’-(aminocarbonyl)[1,1’-biphenyl]-3-yl ester

Synonyms:  Click Tag™ JP104

Molecular weight: 406.5

CAS: 887264-45-1

Purity: ≥98%

Formulation: A crystalline solid

Application|Click Chemistry||Product Type|Biochemicals|Labeling & Detection|Reactive Probes||Product Type|Biochemicals|Small Molecule Inhibitors|Fatty Acid Metabolism||Research Area|Lipid Biochemistry|Endocannabinoid/Endocannabinoid-like||Research Area|Neuroscience|Cannabinoid Research|Endocannabinoids

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