An RSV fusion inhibitor; reduces RSV replication in RSV-infected HeLa cells (IC50 = 0.5 nM) with a CC50 of >50 µM; reduces RSV viral titers in lavaged-lung tissue and viral RNA production in the lungs in a cotton rat RSV model at 4-100 mg/kg administered prior to infection; reduces RSV viral titers in BALF in a neonatal lamb RSV model at 5 and 25 mg/kg per day

JNJ-53718678 – 25 mg

Brand:
Cayman
CAS:
1383450-81-4
Storage:
-20
UN-No:
Non-Hazardous - /

JNJ-53718678 is an inhibitor of respiratory syncytial virus (RSV) fusion.{57280} JNJ-53718678 binds to and stabilizes the RSV fusion protein in its prefusion conformation.{57281} It reduces RSV replication in RSV-infected HeLa cells (IC50 = 0.5 nM) with a 50% cytotoxic concentration (CC50) of greater than 50 µM.{57280} JNJ-53718678 (4-100 mg/kg), administered prior to infection, reduces RSV viral titers in lavaged-lung tissue and viral RNA production in the lungs in a semi-permissive cotton rat model of RSV.{57281} JNJ-53718678 also reduces RSV viral titers in bronchoalveolar lavage fluid (BALF) in a fully replicative neonatal lamb model of RSV when administered at doses of 5 and 25 mg/kg per day.  

 

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SKU: 31720 - 25 mg Category:

Description

An RSV fusion inhibitor; reduces RSV replication in RSV-infected HeLa cells (IC50 = 0.5 nM) with a CC50 of >50 µM; reduces RSV viral titers in lavaged-lung tissue and viral RNA production in the lungs in a cotton rat RSV model at 4-100 mg/kg administered prior to infection; reduces RSV viral titers in BALF in a neonatal lamb RSV model at 5 and 25 mg/kg per day

Formal name: 3-[[5-chloro-1-[3-(methylsulfonyl)propyl]-1H-indol-2-yl]methyl]-1,3-dihydro-1-(2,2,2-trifluoroethyl)-2H-imidazo[4,5-c]pyridin-2-one

Synonyms: 

Molecular weight: 500.9

CAS: 1383450-81-4

Purity: ≥95%

Formulation: A crystalline solid

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