A positive allosteric modulator of mGlurR2 (EC50 = 17 nM in CHO cells expressing the human receptor); inhibits mGluR2-mediated REM sleep in rats at 3 mg/kg; reverses phencyclidine-induced hyperlocomotion in mice (ED50 = 5.4 mg/kg)

JNJ-42153605 – 25 mg

Brand:
Cayman
CAS:
1254977-87-1
Storage:
-20
UN-No:
Non-Hazardous - /

JNJ-42153605 is a positive allosteric modulator of metabotropic glutamate receptor 2 (mGluR2; EC50 = 17 nM in CHO cells expressing the human receptor).{48351} In vivo, JNJ-42153605 (3 mg/kg) inhibits mGluR2-mediated rapid eye movement (REM) sleep in rats. It also reverses phencyclidine-induced hyperlocomotion in mice (ED50 = 5.4 mg/kg).  

 

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Description

A positive allosteric modulator of mGlurR2 (EC50 = 17 nM in CHO cells expressing the human receptor); inhibits mGluR2-mediated REM sleep in rats at 3 mg/kg; reverses phencyclidine-induced hyperlocomotion in mice (ED50 = 5.4 mg/kg)

Formal name: 3-(cyclopropylmethyl)-7-(4-phenyl-1-piperidinyl)-8-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyridine

Synonyms: 

Molecular weight: 400.4

CAS: 1254977-87-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Allosteric Modulators||Research Area|Neuroscience|Behavioral Neuroscience|Schizophrenia & Psychosis||Research Area|Neuroscience|Behavioral Neuroscience|Sleep & Biological Rhythms

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