A potent

JNJ-10397049 – 5 mg

Brand:
Cayman
CAS:
708275-58-5
Storage:
-20
UN-No:
Non-Hazardous - /

JNJ-10397049 is a potent, selective, and bioavailable antagonist of the orexin-2 receptor (OX2R) (KB = 4.5 nM for OX2R versus 1.1 µM for OX1R).{26505,26508,26507} It has no significant affinity for over 50 other neurotransmitters or neuropeptide receptors.{26505} Applied subcutaneously to rats, JNJ-10397049 decreases the latency to persistent sleep and increases persistent sleep time.{26505} This compound produces a widespread attenuation of D-amphetamine-induced relative cerebrovascular signal, with prominent cortical involvement, in rat brains assessed by functional magnetic resonance imaging.{26506}  

 

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Description

A potent, selective, and bioavailable antagonist of the OX2R (KB = 4.5 nM for OX2R versus 1.1 µM for OX1R); decreases the latency to persistent sleep and increases persistent sleep time when applied subcutaneously to rats

Formal name: N-(2,4-dibromophenyl)-N’-[(4S,5S)-2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl]-urea

Synonyms: 

Molecular weight: 484.2

CAS: 708275-58-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Neuroscience|Behavioral Neuroscience|Sleep & Biological Rhythms

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