An imidazopyridine derivative that prevents Gli-dependent transcriptional activity (IC50 = 30 nM) by inhibiting alcohol dehydrogenase 7 (IC50 = 210 nM) and depolymerizing microtubules; antiproliferative in a range of cancer cell lines (GI50s = 3-21 nM) and in pancreatic cancer xenograft models (0.2 mg/mouse/day)

JK 184 – 50 mg

Brand:
Cayman
CAS:
315703-52-7
Storage:
4
UN-No:
Non-Hazardous - /

JK 184 is an imidazopyridine derivative that inhibits downstream hedgehog signaling, preventing Gli-dependent transcriptional activity (IC50 = 30 nM).{24518} It does so by inhibiting alcohol dehydrogenase 7 (IC50 = 210 nM) and depolymerizing microtubules, preventing their assembly, which is crucial for Gli function.{24518,24517} JK 184 exhibits antiproliferative activity in a range of cancer cell lines (L3.6pl, Panc 05.04, BxPC3, D283 med, Daoy; GI50s = 3-21 nM) and in L3.6pl and BxPC3 pancreatic cancer xenograft models (0.2 mg/mouse/day).{24518}  

 

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Description

An imidazopyridine derivative that prevents Gli-dependent transcriptional activity (IC50 = 30 nM) by inhibiting alcohol dehydrogenase 7 (IC50 = 210 nM) and depolymerizing microtubules; antiproliferative in a range of cancer cell lines (GI50s = 3-21 nM) and in pancreatic cancer xenograft models (0.2 mg/mouse/day)

Formal name: N-(4-ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)-2-thiazolamine

Synonyms: 

Molecular weight: 350.4

CAS: 315703-52-7

Purity: ≥99%

Formulation: A pale pink to off-white solid

Product Type|Biochemicals|Microtubule Dynamics||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer|Transcription Factors||Research Area|Cell Biology|Cell Signaling|Hedgehog Signaling||Research Area|Cell Biology|Cytoskeleton & Motor Proteins

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