A SIRT1-specific inhibitor (IC50 = 15 μM); inhibits metastatic breast cancer MDA-MB 231 cell proliferation (IC50 = 512 nM)

JGB1741 – 1 mg

Brand:
Cayman
CAS:
1256375-38-8
Storage:
-20
UN-No:
De Minimis - 3077 / 9

The sirtuins (SIRTs) are a family of NAD+-dependent histone deacetylases involved in gene regulation that is relevant to longevity, cancer, gene regulation, energy homeostasis, and apoptosis.{15106,16291} JGB1741 is a small molecule inhibitor of SIRT1 with an IC50 value of 15 μM in a cell-free assay.{18667} It shows relatively weak inhibition for SIRT2 and SIRT3 with IC50 values greater than 100 μM. JGB1741 inhibits metastatic breast cancer MDA-MB 231 cell proliferation with an IC50 value of 512 nM in a cell-based assay and dose-dependently increases p53 acetylation and p53-mediated apoptosis in these cells.  

 

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SKU: 10641 - 1 mg Category:

Description

A SIRT1-specific inhibitor (IC50 = 15 μM); inhibits metastatic breast cancer MDA-MB 231 cell proliferation (IC50 = 512 nM), dose-dependently increasing p53 acetylation and p53-mediated apoptosis in these cells

Formal name: 4,5,6,7-tetrahydro-2-[(E)-[(2-hydroxy-1-naphthalenyl)methylene]amino]-N-(phenylmethyl)-benzo[b]thiophene-3-carboxamide

Synonyms:  ILS-JGB-1741

Molecular weight: 440.6

CAS: 1256375-38-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Deacetylases||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|p53 Signaling||Research Area|Cancer|Transcription Factors|p53||Research Area|Epigenetics, Transcription, & Translation|Erasers|Histone Deacetylation

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