An inhibitor of the hedgehog signaling pathway (IC50s = 500-700 nM); induces a variety of birth defects in vivo; reduces lipid accumulation and PPARγ and C/EBPα gene expression in 3T3-L1 adipocytes in vitro

Jervine – 5 mg

Brand:
Cayman
CAS:
469-59-0
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Jervine is a naturally occurring teratogenic alkaloid that inhibits the sonic hedgehog pathway (IC50s = 500-700 nM) in vitro.{24330} It induces a variety of birth defects in vivo, including holoprosencephaly, cyclopia, cebocephaly, exencephaly, and microphthalmia in rat, chicken, and sheep.{35059,35060,35061} Jervine also reduces lipid accumulation and PPARγ and C/EBPα gene expression in 3T3-L1 adipocytes in vitro.{35062}  

 

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SKU: 11723 - 5 mg Category:

Description

An inhibitor of the hedgehog signaling pathway (IC50s = 500-700 nM); induces a variety of birth defects in vivo; reduces lipid accumulation and PPARγ and C/EBPα gene expression in 3T3-L1 adipocytes in vitro,

Formal name: (2’R,3S,3’R,3’aS,6’S,6aS,6bS,7’aR,11aS,11bR)-2,3,3’a,4,4’,5’,6,6’,6a,6b,7,7’,7’a,8,11a,11b-hexadecahydro-3-hydroxy-3’,6’,10,11b-tetramethyl-spiro[9H-benzo[a]fluorene-9,2’(3’H)-furo[3,2-b]pyridin]-11(1H)-one

Synonyms:  NSC 23898|NSC 7520

Molecular weight: 425.6

CAS: 469-59-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Alkaloids||Research Area|Cell Biology|Cell Signaling|Hedgehog Signaling||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Obesity

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