An inhibitor of palmitoyl protein thioesterase-1; enhances invasion of Toxoplasma tachyzoites into BSC-1 host cells

JCP174 – 1 mg

Brand:
Cayman
CAS:
126062-19-9
Storage:
-20
UN-No:
Non-Hazardous - /

JCP174 is an inhibitor of palmitoyl protein thioesterase-1 (TgPPT1), a depalmitoylase in the parasite T. gondii.{46378} JCP174 enhances invasion of Toxoplasma tachyzoites into BSC-1 host cells, increasing the number of attached and invaded parasites when used at a concentration of 50 µM, enhancing plaque formation at concentrations of 0.5 and 50 µM, and increasing gliding motility. JCP174 is also an inhibitor of porcine pancreatic elastase and human leukocyte elastase.{46379,46380}  

 

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Description

An inhibitor of palmitoyl protein thioesterase-1; enhances invasion of Toxoplasma tachyzoites into BSC-1 host cells, increasing the number of attached and invaded parasites at 50 µM, enhancing plaque formation at 0.5 and 50 µM, and increasing gliding motility; an inhibitor of porcine pancreatic elastase and human leukocyte elastase

Formal name: 7-amino-4-chloro-3-propoxy-1H-2-benzopyran-1-one

Synonyms:  ,7-amino-4-chloro-3-Propoxyisocoumarin

Molecular weight: 253.7

CAS: 126062-19-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Research Area|Cell Biology|Proteolysis|Cytosolic & Secreted Proteases||Research Area|Cell Biology|Proteolysis|Lysosomal Proteases||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Parasitic Diseases|Toxoplasmosis

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