A selective inhibitor of the autophosphorylation of wild type and V617F mutant forms of JAK2

JAK2 Inhibitor V – 1 mg

Brand:
Cayman
CAS:
195371-52-9
Storage:
-20
UN-No:
Non-Hazardous - 1170 / 3

Janus-associated kinases (JAKs) are cytoplasmic tyrosine kinases that are required for activating the signaling of certain cytokines and growth factor receptors. Many myeloproliferative diseases have been linked to a mutation in JAK2 in which a switch from valine to phenylalanine occurs at the 617 position (V617F).{27171} JAK2 Inhibitor V is an inhibitor of the autophosphorylation of wild type and V617F mutant forms of JAK2, displaying IC50 values between 10 and 30 µM.{30753} It has no effect on Tyk2 or c-Src kinase function. JAK2 Inhibitor V blocks the proliferation of erythroleukemia cells and human hematopoietic progenitor cells expressing JAK2-V617F.{30753}  

 

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Description

A selective inhibitor of the autophosphorylation of wild type and V617F mutant forms of JAK2, displaying IC50 values between 10 and 30 µM; blocks the proliferation of erythroleukemia cells and human hematopoietic progenitor cells expressing JAK2-V617F ,

Formal name: 2-​methyl-​1-​phenyl-​4-​(2-​pyridinyl)​-​2-​[2-​(2-​pyridinyl)​ethyl]​-​1-​butanone

Synonyms:  Janus-Associated Kinase Inhibitor V|NSC 42834|Z3

Molecular weight: 344.5

CAS: 195371-52-9

Purity: ≥95%

Formulation: A solution in ethanol

Product Type|Biochemicals|Kinase Inhibitors|JAK Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|JAK/STAT Signaling||Research Area|Cell Biology|Cell Signaling|JAK Signaling

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