The minor component (

Ivermectin B1b – 500 µg

Brand:
Cayman
CAS:
70209-81-3
Storage:
-20
UN-No:
Non-Hazardous - /

Ivermectin B1b is the minor component (1a (>80%; Item No. 18768).{39419} It produces antiparasitic activity by binding to glutamate-gated chloride channels expressed on nematode neurons and pharyngeal muscle cells, inducing irreversible channel opening and very long-lasting hyperpolarization/depolarization of the neuron/muscle cell, thereby blocking further function.{30216,28250} Formulations containing ivermectin inhibit replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Vero/hSLAM cells.{55038}  

 

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SKU: 23824 - 500 µg Category:

Description

The minor component (<20%) of ivermectin; binds to glutamate-gated chloride channels, inducing irreversible channel opening; ivermectin inhibits replication of SARS-CoV-2 in Vero/hSLAM cells ,

Formal name: 5-O-demethyl-25-de(1-methylpropyl)-22,23-dihydro-25-(1-methylethyl)-avermectin A1a

Synonyms:  22,23-dihydro Avermectin B1b

Molecular weight: 861.1

CAS: 70209-81-3

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Antiparasitics|Anthelmintics||Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Ion Channel Modulation|Activators||Research Area|Immunology & Inflammation|Pulmonary Diseases|COVID-19||Research Area|Infectious Disease|Parasitic Diseases||Research Area|Infectious Disease|Viral Diseases|Coronaviruses

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