The main component (>80%) of ivermectin; binds to glutamate-gated chloride channels

Ivermectin B1a – 5 mg

Brand:
Cayman
CAS:
71827-03-7
Storage:
-20
UN-No:
Non-Hazardous - /

Ivermectin B1a is the main component (>80%) of the anthelmintic ivermectin, which also contains ivermectin B1b (23824).{39419} It produces antiparasitic activity by binding to glutamate-gated chloride channels expressed on nematode neurons and pharyngeal muscle cells, inducing irreversible channel opening and very long-lasting hyperpolarization/depolarization of the neuron/muscle cell, thereby blocking further function (EC50 = 104 nM).{30216,28250} Formulations containing ivermectin inhibit replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Vero/hSLAM cells.{55038}  

 

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Description

The main component (>80%) of ivermectin; binds to glutamate-gated chloride channels, inducing irreversible channel opening; ivermectin inhibits replication of SARS-CoV-2 in Vero/hSLAM cells

Formal name: 5-O-demethyl-22,23-dihydro-avermectin A1a

Synonyms:  22,23-dihydro Avermectin B1a

Molecular weight: 875.1

CAS: 71827-03-7

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Antiparasitics|Anthelmintics||Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Ion Channel Modulation|Activators||Research Area|Immunology & Inflammation|Pulmonary Diseases|COVID-19||Research Area|Infectious Disease|Parasitic Diseases||Research Area|Infectious Disease|Viral Diseases|Coronaviruses||Research Area|Neuroscience

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