Description
An antifungal agent and hedgehog pathway inhibitor; inhibits hedgehog signaling (IC50 = 0.8 μM); binds to 14-α sterol demethylase/CYP51 isoform B (Kd = 31 nM for A. fumigatus enzyme expressed in E. coli); inhibits ergosterol biosynthesis in C. neoformans (IC50 = 6 nM after 16 hours); inhibits C. neoformans growth by 50% at 3.2 nM; suppresses growth of medulloblastomas in a Ptch+/-p53-/- mouse allograft model at 100 mg/kg twice daily; reduces viral titers of several enteroviruses in infected cells from 1.25-100 µM
Formal name: 4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(1-methylpropyl)-3H-1,2,4-triazol-3-one
Synonyms:
Molecular weight: 705.6
CAS: 84625-61-6
Purity: ≥95%
Formulation: A crystalline solid
Product Type|Biochemicals|Antifungals|Triazoles||Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Small Molecule Inhibitors|Cytochrome P450||Product Type|Biochemicals|Small Molecule Inhibitors|Demethylases||Product Type|Biochemicals|Small Molecule Inhibitors|Sterol Biosynthesis||Research Area|Cancer|Cell Signaling|Hedgehog Signaling||Research Area|Cell Biology|Cell Signaling|Hedgehog Signaling||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Fungal Diseases|Aspergillosis||Research Area|Infectious Disease|Viral Diseases|Rhinoviruses
