An AChE inhibitor (IC50 = 1.6 µM for rat stomach enzyme) and a prokinetic agent; induces contractions in isolated rabbit duodenum from 1-100 µM; enhances ACh-induced contractions in isolated guinea pig stomach circular muscle strips; enhances normal gastric antral motility and improves clonidine-induced gastric antral hypomotility and delayed gastric emptying in rats at 100 mg/kg

Itopride (hydrochloride) – 5 mg

Brand:
Cayman
CAS:
122892-31-3
Storage:
-20
UN-No:
De Minimis - 3077 / 9

Itopride is an inhibitor of acetylcholinesterase (AChE; IC50 = 1.6 µM for rat stomach enzyme) and a prokinetic agent.{58108} It induces contractions in isolated rabbit duodenum when used at concentrations ranging from 1 to 100 µM and enhances ACh-induced contractions in isolated guinea pig stomach circular muscle strips.{58109,58110} Itopride (100 mg/kg) enhances normal gastric antral motility and improves gastric antral hypomotility and delayed gastric emptying induced by clonidine (Item No. 15949) in rats.{58108} Formulations containing itopride have been used in the treatment of functional dyspepsia.  

 

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Description

An AChE inhibitor (IC50 = 1.6 µM for rat stomach enzyme) and a prokinetic agent; induces contractions in isolated rabbit duodenum from 1-100 µM; enhances ACh-induced contractions in isolated guinea pig stomach circular muscle strips; enhances normal gastric antral motility and improves clonidine-induced gastric antral hypomotility and delayed gastric emptying in rats at 100 mg/kg

Formal name: N-[[4-[2-(dimethylamino)ethoxy]phenyl]methyl]-3,4-dimethoxy-benzamide, monohydrochloride

Synonyms: 

Molecular weight: 394.9

CAS: 122892-31-3

Purity: ≥98%

Formulation: A crystalline solid

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