A PDE1 inhibitor (Ki = 0.058 nM); selective for PDE1 over PDE2A

ITI214 – 5 mg

Brand:
Cayman
CAS:
1642303-38-5
Storage:
-20
UN-No:
Non-Hazardous - /

ITI214 is an inhibitor of phosphodiesterase 1 (PDE1; Ki = 0.058 nM).{54039} It is selective for PDE1 over PDE2A, -3B, -4A, -5A, -6, -7B, -8A, -9A, -10A, and -11A (Kis = 0.16-18 µM). ITI214 (3 and 6 mg/kg) enhances novel object recognition in rats. It increases prefrontal cortex cAMP and cGMP levels in mice when administered at a dose of 50 mg/kg.{54040} ITI214 (0.1, 3, and 10 mg/kg) reverses MK-801-induced decreases in spontaneous alteration in the T-maze continuous alternation task in mice.  

 

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SKU: 30376 - 5 mg Category:

Description

A PDE1 inhibitor (Ki = 0.058 nM); selective for PDE1 over PDE2A, -3B, -4A, -5A, -6, -7B, -8A, -9A, -10A, and -11A (Kis = 0.16-18 µM); enhances novel object recognition in rats at 3 and 6 mg/kg; increases prefrontal cortex cAMP and cGMP levels in mice at 50 mg/kg; reverses MK-801-induced decreases in spontaneous alteration in the T-maze continuous alternation task in mice at 0.1, 3, and 10 mg/kg

Formal name: (6aR,9aS)-2-[[4-(6-fluoro-2-pyridinyl)phenyl]methyl]-5,6a,7,8,9,9a-hexahydro-5-methyl-3-(phenylamino)-cyclopent[4,5]imidazo[1,2-a]pyrazolo[4,3-e]pyrimidin-4(2H)-one, monophosphate

Synonyms: 

Molecular weight: 605.6

CAS: 1642303-38-5

Purity: ≥98%

Formulation: A solid

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